TABLE 2.
In vitro susceptibility to fluconazole, AUC/MIC, dosewn/MIC, and mortality according to common isolated species at 24 h
| Candida sp. (n) | MIC50 (μg/ml) (range) | Mean AUC/MIC ± SD (range) | Mean dosewn/MIC ± SD (range) | Mortality rate (%) |
|---|---|---|---|---|
| C. albicans (49) | 0.25 (0.25-128) | 946 ± 764 (0.58-3,097) | 15.4 ± 10.0 (0.035-35.6) | 16.3 |
| C. glabrata (11) | 4.0 (0.25-16.0) | 182 ± 427 (11.2-430) | 1.9 ± 2.2 (0.30-7.9) | 36.4 |
| C. parapsilosis (6) | 1.25 (0.25-2.0) | 635 ± 500 (59.9-1,050) | 10.7 ± 11.0 (1.18-26.7) | 0 |
| C. tropicalis (5) | 1.0 (0.25-4.0) | 657 ± 788 (58.6-1,774) | 11.4 ± 12.2 (1.23-32.7) | 0 |
| C. lusitaniae (3) | 2.0 (1.0-4.0) | 232 ± 214 (27.8-462.2) | 3.3 ± 1.6 (0.78-12.9) | 33.3 |