TABLE 6.

QTcB and QTcF changes from baseline^a

Parameter	Criterion (ms)	Methadone + voriconazole			Methadone + placebo
		Total no. of patients	No. of patients that met criteria	% of patients that met criteria	Total no. of patients	No. of patients that met criteria	% of patients that met criteria
QTcBb	≥450	16	5	31.3	7	2	28.6
	30-<60d	16	4	25.0	7	1	14.3
QTcFc	≥450	16	6	37.5	7	2	28.6
	30-<60d	16	4	25.0	7	1	14.3

^aBaseline was the time-matched average of the triplicate values taken at predose and at 2, 4, and 8 h on day 2 (methadone alone).

^bQTc corrected for heart rate using Bazett's formula: QT/(60/HR).

^cQTc corrected for heart rate using Fridericia's formula: QT/(60/HR).

^dMaximum increase from baseline.