TABLE 1.
Clinical characteristics, serotypes, PFGE profiles, and STs of international PNSP clones
| Pneumococcal clone | STa | Allelic profilea,b | Serotype | PFGE type(s) | No. of isolates | Site(s) of isolationc,d | Yr of isolation | pbp profilee | MIC (μg/ml)f
|
|||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PEN | AMX | CXM | CRO | FEP | MEM | |||||||||
| Spain23F-1 | 81 | 4-4-2-4-4-1-1 | 23F | 1a | 1-1-1 | |||||||||
| 81 | 4-4-2-4-4-1-1 | 23F | 1a, f, g, h, j, k, l, m, n, o, p, 2 | 20 | Sputum, BAL, CSF, blood | 1997-2002 | 1-1-1 | 2 | 1 | 4 | 1 | 1 | 0.5 | |
| 81 | 4-4-2-4-4-1-1 | 19A | 1d | 1 | BAL | 1997 | 1-1-1 | 2 | 2 | 8 | 2 | 1 | 1 | |
| 81 | 4-4-2-4-4-1-1 | 19F | 1b, c | 2 | Sputum | 1995, 2002 | 1-1-1 | 2 | 2 | 4-8 | 1 | 1 | 0.5 | |
| 1051 | 4-4-2-4-53-1-1 | 23F | 1i | 1 | Sputum | 1999 | 1-1-1 | 2 | 1 | 4 | 1 | 1 | 0.5 | |
| 1476 | 4-4-2-4-104-1-1 | 23F | 1f | 1 | Sputum | 1998 | 1-1-1 | 2 | 2 | 8 | 1 | 1 | 0.5 | |
| Spain6B-2 | 90 | 5-5-1-2-6-3-4 | 6B | 3a | 1-2-other | |||||||||
| 90 | 5-5-1-2-6-3-4 | 6B | 3a, b | 3 | CSF, sputum | 1999, 2001 | 1-2-2 | 2 | 1 | 4-8 | 1 | 1 | 0.5 | |
| Spain9V-3 | 156 | 7-11-10-1-6-8-1 | 9V | 4a | 1-1-1 | |||||||||
| 156 | 7-11-10-1-6-8-1 | 9V | 4a, b, e, f, g, h, i | 18 | Sputum, BAL, CSF, sinus | 1995, 1999, 2000-2002 | 1-1-1 | 2 | 0.5-2 | 2-8 | 0.5-1 | 0.5-1 | 0.25-0.5 | |
| 156 | 7-11-10-1-6-8-1 | 9V | 4h | 1 | CSF | 2002 | 2-1-1 | 1 | 1 | 4 | 0.5 | 0.5 | 0.5 | |
| 156 | 7-11-10-1-6-8-1 | 14 | 4b, c, d, e | 4 | Sputum, CSF | 2000, 2002 | 1-1-1 | 2 | 1 | 4-16 | 1-2 | 1 | 0.5 | |
| 156 | 7-11-10-1-6-8-1 | Rough | 5 | 1 | Sputum | 2002 | 1-1-1 | 2 | 1 | 8 | 1 | 1 | 0.25 | |
| 557 | 7-11-10-1-6-58-1 | 9V | 4e | 1 | CSF | 2000 | 1-1-1 | 2 | 1 | 2 | 0.5 | 0.5 | 0.5 | |
| Taiwan23F-15 | 242 | 15-29-4-21-30-1-14 | 23F | 7 | 3-1-3 | |||||||||
| 242 | 15-29-4-21-30-1-14 | 23F | 7 | 1 | Sputum | 2000 | 3-1-3 | 4 | 2 | 8 | 2 | 1 | 0.5 | |
| 242 | 15-29-4-21-30-1-14 | 23F | 8 | 1 | Blood | 2002 | 3-3-3 | 4 | 4 | 8 | 2 | 1 | 1 | |
| Poland23F-16 | 173 | 7-13-8-1-10-6-36 | 23F | 9 | 4-1-4 | |||||||||
| 173 | 7-13-8-1-10-6-36 | 23F | 9 | 1 | Blood | 1998 | 4-1-4 | 4 | 2 | 16 | 2 | 1 | 0.5 | |
| 173 | 7-13-8-1-10-6-36 | 23F | 10c | 1 | CSF | 1997 | 4-4-4 | 8 | 2 | 4 | 0.5 | 2 | 0.5 | |
| 173 | 7-13-8-1-10-6-36 | 23F | 10d | 1 | BAL | 1997 | 4-5-5 | 8 | 16 | >32 | 4 | 8 | 0.5 | |
| 272 | 7-13-8-1-10-6-37 | 23F | 11a | 3 | BAL, sputum | 2000 | 4-6-5 | 8 | 8-16 | ≥32 | 2-4 | 1-2 | 0.5 | |
| 272 | 7-13-8-1-10-6-37 | 23F | 11e, f | 3 | BAL, eye, sputum | 1998, 2000 | 4-7-5 | 8 | 8 | 4-16 | 1-2 | 1 | 0.25 | |
| 272 | 7-13-8-1-10-6-37 | 23F | 11b, c, d | 3 | CSF, blood | 2002 | 4-8-5 | 4-8 | 8 | 32 | 2-4 | 1 | 0.5 | |
| 1482 | 7-13-8-1-100-6-36 | 23F | 10a | 1 | Eye | 1997 | 5-4-4 | 0.5 | 0.25 | 1 | 0.25 | 0.25 | 0.06 | |
| 1506 | 7-13-8-1-10-6-162 | 23F | 10b | 1 | BAL | 1997 | 4-4-6 | 4 | 4 | 2 | 0.25 | 1 | 0.25 | |
| Poland6B-20 | 315 | 20-28-1-1-15-14-14 | 6B | 12a | WT-9-WT | |||||||||
| 315 | 20-28-1-1-15-14-14 | 6B | 12a, d, g | 14 | Sputum, ear, blood, BAL, CSF | 1995-1996, 1998, 2001-2002 | WT-9-WT | 0.12 | 0.06-0.12 | 0.12-0.25 | 0.06 | 0.06-0.12 | 0.06 | |
| 315 | 20-28-1-1-15-14-14 | 6B | 13 | 1 | Sputum | 1998 | 6-10-WT | 2 | 1 | 2 | 0.25 | 1 | 0.25 | |
| 315 | 20-28-1-1-15-14-14 | 6B | 12a | 2 | Sputum, sinus | 1999, 2001 | 7-11-WT | 0.5 | 0.25 | 0.25 | 0.25 | 0.25 | 0.12 | |
| 315 | 20-28-1-1-15-14-14 | 6B | 12c, e | 2 | Ear, sputum | 1995 | NT-7-3 | 2 | 1-2 | 2 | 1 | 1 | 0.25 | |
| 316 | 1-28-1-1-15-14-14 | 6B | 12b | 1 | Blood | 1998 | WT-9-WT | 0.12 | 0.12 | 0.12 | 0.06 | 0.06 | 0.06 | |
| 606 | 16-28-1-1-15-14-14 | 6B | 12d | 1 | CSF | 1998 | WT-9-WT | 0.12 | 0.12 | 0.06 | 0.06 | 0.06 | ||
| 1032 | 20-28-1-1-6-14-14 | 6B | 12h, i | 2 | Sputum | 2001 | WT-9-WT | 0.12 | 0.12 | 0.12 | 0.06 | 0.06 | 0.06 | |
| 1052 | 20-28-1-8-15-14-14 | 6B | 12f | 1 | Pleural fluid | 1996 | WT-9-WT | 0.12 | 0.12 | 0.06 | 0.06 | 0.06 | ||
| 1505 | 20-28-1-1-105-14-14 | 6B | 12b | 1 | Sputum | 2002 | WT-9-WT | 0.12 | 0.12 | 0.12 | 0.06 | 0.06 | 0.06 | |
| Sweden15A-25 | 63 | 2-5-36-12-17-21-14 | 15A | 14 | Other-12-4 | |||||||||
| 63 | 2-5-36-12-17-21-14 | 15A | 14 | 1 | Sputum | 1999 | 8-12-4 | 0.25 | ≤0.03 | 0.12 | 0.06 | 0.06 | ≤0.03 | |
a
New STs and alleles are underlined.
b
In the order aroE-gdh-gki-recP-spi-xpt-ddl.
c
BAL, bronchoalveolar lavage; CSF, cerebrospinal fluid.
d
Susceptibilities, serotypes, and STs of meningitis-related isolates were described in reference 39, and ciprofloxacin-nonsusceptible isolates (single isolates of ST81, ST276, and ST1477 and two isolates of ST156) were described in reference 38.
e
In the order pbp1a-pbp2x-pbp2b. NT, nontypeable; other, pattern unique to an ATCC clone.
f
PEN, penicillin; AMX, amoxicillin; CXM, cefuroxime; CRO, ceftriaxone; FEP, cefepime; MEM, meropenem.