TABLE 1.
Susceptibilities of wild types and E. coli J53 transconjugants to β-lactam and quinolone antibiotics
| Straina | MIC (μg/ml)b
|
qnrB allele | β-Lactamase | ||||||
|---|---|---|---|---|---|---|---|---|---|
| NA | CIP | LEVO | MOXI | FOX | CTX | CAZ | |||
| E. coli J53 Azir | 8 | 0.03 | 0.06 | 0.06 | 4 | <0.25 | 1 | ||
| 12-1183 | >64 | >16 | >16 | >8 | >128 | 16 | 128 | B4 | DHA-1 |
| T12-1183 | 32 | 0.25 | 0.5 | 1 | 32 | 4 | 128 | ||
| 35 | >64 | 16 | 4 | >8 | 32 | >128 | >128 | B5 | SHV-12 |
| T35 | 32 | 0.5 | 0.25 | 0.5 | 4 | 16 | 128 | ||
| 07-006 | >64 | 16 | 8 | 8 | 16 | 64 | 128 | B2 | SHV-12 |
| T07-006 | 32 | 0.5 | 0.25 | 1 | 4 | 16 | 128 | ||
| 03-222 | >64 | 16 | 16 | 8 | 16 | 4 | 128 | B2 | SHV-12 |
| T03-222 | 32 | 1 | 0.25 | 0.5 | 4 | 2 | 64 | ||
| 12-1502 | 16 | 0.5 | 0.25 | 0.5 | >128 | 64 | 128 | B2 | CMY-1 |
| T12-1502 | 32 | 1 | 0.25 | 0.5 | >128 | 64 | 64 | ||
a
T, an E. coli J53 Azir transconjugant of each isolate. Isolate 12-1502 was E. coli, and all other clinical isolates were K. pneumoniae.
b
NA, nalidixic acid; CIP, ciprofloxacin; LEV, levofloxacin; MOX, moxifloxacin; FOX, cefoxitin; CTX, cefotaxime; CAZ, ceftazidime.