TABLE 1.

MICs and MBCs of lipopeptides and other clinically used antibiotics for clinical isolates

Strain (no. of isolates) and agent	MIC (mg/liter)			MBC (mg/liter)
	Range	50%	90%	Range	50%	90%
MR S. aureus (30)
Pal-Lys-Lys-NH2	2-16	4	8	2-32	8	16
Pal-Lys-Lys	2-32	4	8	2-32	8	16
Imipenem	1-128	16	128	8-128	64	256
Doxycycline	0.50-16	4	16	4-64	8	32
Clarithromycin	1-32	4	32	4-128	32	128
Linezolid	0.25-2	0.5	1	0.50-4	0.5	2
Vancomycin	0.12-4	0.5	2	0.50-4	0.5	2
Amoxicillin	4-128	32	128	8-128	64	256
MS S. aureus (30)
Pal-Lys-Lys-NH2	2-16	4	8	2-16	8	16
Pal-Lys-Lys	2-16	4	8	2-32	8	16
Imipenem	0.25-4	0.5	2	0.5-32	4	8
Doxycycline	0.50-8	2	8	2-32	8	32
Clarithromycin	0.50-16	4	8	2-64	16	64
Linezolid	0.12-2	0.5	2	0.50-2	1	2
Vancomycin	0.12-2	0.5	1	0.50-2	0.5	2
Amoxicillin	0.25-8	1	4	0.50-32	8	16
VS Enterococcus faecalis (30)
Pal-Lys-Lys-NH2	2-16	2	4	2-32	4	8
Pal-Lys-Lys	2-16	2	4	2-32	4	8
Imipenem	1-64	4	16	4-256	16	64
Doxycycline	1-32	4	32	4-128	16	64
Clarithromycin	4-128	8	32	8-256	32	128
Linezolid	0.50-4	1	2	0.5-4	2	4
Vancomycin	0.25-4	1	2	1-4	2	4
Amoxicillin	1-32	4	16	4-64	16	64
VR Enterococcus faecalis (14)
Pal-Lys-Lys-NH2	2-16	2	4	2-32	4	16
Pal-Lys-Lys	2-32	2	4	2-64	4	16
Imipenem	4-128	16	64	8-256	64	128
Doxycycline	2-64	16	64	8-64	16	64
Clarithromycin	8-128	16	64	16-256	32	256
Linezolid	0.50-4	1	2	1-4	4	4
Vancomycin	32-128	32	64	64-256	64	256
Amoxicillin	4-128	16	64	8-256	64	128
Streptococcus pyogenes (30)
Pal-Lys-Lys-NH2	1-8	1	2	2-16	2	4
Pal-Lys-Lys	1-8	1	2	2-16	2	4
Imipenem	0.25-2	0.50	1	0.5-4	1	4
Doxycycline	0.50-8	2	8	1-32	8	16
Clarithromycin	0.50-8	4	8	1-64	8	32
Linezolid	0.12-2	0.5	1	0.50-2	1	2
Vancomycin	0.25-2	0.5	1	0.50-2	1	2
Amoxicillin	0.06-2	0.25	2	0.5-16	4	8
Rhodococcus equi (12)
Pal-Lys-Lys-NH2	2-16	4	16	4-32	8	32
Pal-Lys-Lys	2-16	2	16	2-16	4	16
Imipenem	0.25-2	0.25	1	2-16	8	16
Doxycycline	0.50-4	1	2	8-256	32	128
Clarithromycin	0.50-2	0.50	2	16-128	32	64
Linezolid	0.25-2	0.50	1	4-32	8	16
Vancomycin	0.25-2	0.50	1	2-16	8	16
Amoxicillin	0.25-4	1	2	2-32	8	32