. 2006 Oct 23;51(1):354–358. doi: 10.1128/AAC.00344-06

TABLE 2.

Results of studies of interaction between lipopeptides and other drugs^c

Peptide and combination agent	Mean (range) FIC index
Peptide and combination agent	Staphylococcus aureus	Enterococcus faecalis	Rhodococcus equi	Streptococcus pyogenes
Pal-Lys-Lys-NH₂
Imipenem	0.46 (0.31-0.75)^a	0.31 (0.19-0.50)^a	0.31 (0.19-0.50)^a	0.46 (0.31-0.75)^a
Doxycycline	1.17 (0.75-2.00)^b	1.83 (1.50-2.00)^b	1.83 (1.50-2.00)^b	1.46 (1.00-2.00)^b
Clarithromycin	1.50 (1.00-2.00)^b	1.17 (0.75-2.00)^b	1.46 (1.00-2.00)^b	1.46 (1.00-2.00)^b
Linezolid	1.50 (1.00-2.00)^b	1.46 (1.25-2.00)^b	1.17 (0.75-2.00)^b	1.50 (1.000-2.00)^b
Vancomycin	0.46 (0.31-0.75)^a	0.31 (0.19-0.50)^a	0.39 (0.31-0.50)^a	0.39 (0.31-0.50)^a
Amoxicillin	0.31 (0.19-0.50)^a	0.39 (0.31-0.50)^a	0.31 (0.19-0.50)^a	0.39 (0.31-0.50)^a
Pal-Lys-Lys
Imipenem	0.31 (0.18-0.50)^a	0.31 (0.19-0.50)^a	0.39 (0.31-0.50)^a	0.31 (0.19-0.50)^a
Doxycycline	1.50 (1.00-2.00)^b	1.83 (1.50-2.00)^b	1.17 (1.00-1.50)^b	1.50 (1.00-2.00)^b
Clarithromycin	1.17 (0.75-2.00)^b	1.83 (1.50-2.00)^b	1.46 (1.00-2.00)^b	1.46 (1.00-2.00)^b
Linezolid	0.91 (0.750-1.25)^b	1.17 (1.00-1.50)^b	0.92 (0.75-1.25)^b	1.29 (0.75-2.00)^b
Vancomycin	0.46 (0.31-0.75)^a	0.39 (0.31-0.50)^a	0.46 (0.31-0.75)^a	0.46 (0.31-0.75)^a
Amoxicillin	0.31 (0.19-0.50)^a	0.39 (0.31-0.50)^a	0.31 (0.19-0.50)^a	0.31 (0.19-0.50)^a

Synergy.

Indifference.

The ranges of concentrations tested were 0.125 to 64 mg/liter for lipopeptides and 0.25 to 256 mg/liter for the other antimicrobial agents. Six strains for each genus were tested. Antagonism was absent for all combinations tested.