TABLE 7.
Development of resistance to compounds on liquid medium using the serial passage method with S. aureus
| Compound for passage | Compound for MIC test | Increase in MIC over wild-type S. aureus (fold) at passage:
|
||||||
|---|---|---|---|---|---|---|---|---|
| Nonea | 3 | 6 | 9 | 12 | 15 | 17 | ||
| 251D | 251D | 1 | 4 | 8 | 16 | 16 | 16 | 16 |
| HB-EMAU | 1 | 1 | 2 | 4 | 8 | 16 | 32 | |
| 340E | 1 | 4 | 8 | 8 | 16 | 16 | 16 | |
| 251D | 1 | 2 | 4 | 4 | 2 | 4 | 4 | |
| HB-EMAU | HB-EMAU | 1 | 2 | 8 | >32b | >32 | >32 | >32 |
| 340E | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |
| 251D | 1 | 2 | 4 | 4 | 2 | 4 | 4 | |
| HB-EMAU | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |
| 340E | 340E | 1 | 4 | 8 | 16 | 8 | 8 | 16 |
a
Prior to passage.
b
Increase in MIC exceeded the solubility limit for this compound.