. 2006 Nov 13;51(2):503–509. doi: 10.1128/AAC.00400-06

TABLE 6.

Inhibition of wild-type and S282T mutant HCV NS5B RNA polymerase by the nucleoside triphosphate analogs^a

Nucleotide analog	Wild type			S282T mutant			Fold resistance (K_i/K_m)_mut/ (K_i/K_m)_WTc
Nucleotide analog	K_m (μM)^b	K_i (μM)	K_i/K_m	K_m (μM)^c	K_i (μM)	K_i/K_m	Fold resistance (K_i/K_m)_mut/ (K_i/K_m)_WTc
PSI-6130-TP	13.7 ± 2.59	4.3 ± 0.7	0.31	2.7 ± 0.92	2.5 ± 0.9	0.93	3
2′-C-Me-CTP	13.7 ± 2.59	1.6 ± 0.3	0.12	2.7 ± 0.92	3.8 ± 1.0	1.4	12
2′-C-Me-ATP	2.7 ± 0.66	1.5 ± 0.4	0.56	0.26 ± 0.14	21.8 ± 4.7	84	150

Values are reported means ± standard deviations.

The K_m for CTP is shown for PSI-6130-TP and 2′-C-Me-CTP, and the K_m for ATP is shown for 2′-C-Me-ATP.

mut, mutant; WT, wild type.