TABLE 1.

Steady-state pharmacokinetic parameters for voriconazole

Pharmacokinetic parameter	Sequence	Resulta		Statistical comparisonb
		Day 4	Day 24	Geometric mean ratio (%)	90% CI	Adjusted ratio (90% CI)
AUC0-12 (μg · h/ml)	I	15.2 ± 11.77	13.6 ± 13.55	80.7	73.4 to 88.8	92.4 (80.2 to 106.4)
	II	15.4 ± 10.24	14.0 ± 10.24	87.4	78.9 to 96.8
Cmax (μg/ml)	I	2.6 ± 1.0	2.5 ± 1.6	88.3	76.9 to 101.4	98.1 (80.1 to 120.2)
	II	2.7 ± 1.1	2.5 ± 1.2	90.0	77.9 to 104.1

^aResult (arithmetic mean ± standard deviation) after administration of voriconazole alone or in combination with micafungin (sequence I) or placebo (sequence II).

^bCI, confidence interval.