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VRT-125853 and VRT-752586 cause a reduction in steady-state levels of plasmid supercoiling in E. coli. The effects of VRT-125853, VRT-752586, and novobiocin on the steady-state levels of plasmid DNA supercoiling were determined with E. coli cells, as described in Materials and Methods. The MIC of each compound is circled. The positions of migration of the supercoiled (S) and relaxed (R) DNA forms of plasmid DNA are indicated. M, DNA size marker (sizes are indicated on the left).
