TABLE 4.

Dual targeting leads to lower frequencies of spontaneous resistance to VRT-752586 in E. faecalis

Mutation		VRT-752586 resistance frequency at:			VRT-752586 MIC (μg/ml)
GyrB	ParE	2× MIC	4× MIC	8× MIC
WTa	WT	<5.2 × 10−10	<5.2 × 10−10	<5.2 × 10−10	0.032
WT	T169A	8.7 × 10−9	5.2 × 10−9	1.2 × 10−9	0.064
T167A	WT	9.1 × 10−7	2.4 × 10−8	6.0 × 10−9	0.032
T167A	T169A	1.2 × 10−8	3.7 × 10−8	1.2 × 10−8	0.500

^aWT, wild type.