TABLE 2.
Mean pharmacokinetic parameters of posaconazole on day 8 after multiple-dose administration of posaconazole at 400 mg twice a day
| Parameter | Men and women, pooled
|
Young subjects (18-45 yr old)
|
Elderly subjects (≥65 yr old)
|
|||
|---|---|---|---|---|---|---|
| Young (18-45 yr old) (n = 24) | Elderly (≥65 yr old) (n = 24) | Men (n = 13) | Women (n = 11) | Men (n = 12) | Women (n = 12) | |
| Cmax (ng/ml) (CV) | 2,607 (40) | 3,374 (38) | 2,682 (51) | 2,517 (18) | 3,250 (36) | 3,498 (40) |
| Median Tmax (h) (range) | 5 (4-8) | 5 (0-12) | 4 (4-8) | 5 (4-8) | 5 (0-6) | 6 (0-12) |
| AUC0-12 (ng · h/ml) (CV) | 26,740 (40) | 35,444 (39) | 27,784 (51) | 25,507 (20) | 32,963 (35) | 37,924 (43) |
| t&12frac; (h) (CV) | 31.6 (18)a,b | 41.8 (27)b,c | 31.3 (21)b,d | 31.9 (14)b,e | 37.7 (21)b,f | 42.4 (NC)b,g,h |
| CL/F (liters/h) (CV) | 33.1 (29) | 26.7 (45) | 33.5 (35) | 32.6 (22) | 28.1 (45) | 25.4 (46) |
a
n = 18.
b
t&12frac; could not be determined for some subjects because the number of samples collected during the terminal elimination phase was insufficient.
c
n = 9.
d
n = 10.
e
n = 8.
f
n = 6.
g
n = 2.
h
NC, not calculated. CV could not be calculated for <3 subjects.