TABLE 3.
Statistical comparisons on days 1 and 8, based on log-transformed data, expressed as the ratios of the categories of subjects compared
| Parameter and ratio | Relative bioavailability (%) | 90% CI | ||
|---|---|---|---|---|
| Day 1
|
||||
| Cmax (ng/ml)
|
||||
| Young women/young men | 101 | 79-129 | ||
| Elderly women/elderly men | 70.6 | 55-90 | ||
| Elderly/younga | 120 | 100-143 | ||
| AUC0-12 (ng · h/ml)
|
||||
| Young women/young men | 98.9 | 79-124 | ||
| Elderly women/elderly men | 76.1 | 61-95 | ||
| Elderly/younga | 113 | 96-133 | ||
| Day 8
|
||||
| Cmax (ng/ml)
|
||||
| Young women/young men | 100 | 77-129 | ||
| Elderly women/elderly men | 107 | 83-138 | ||
| Elderly/younga | 126 | 106-150 | ||
| AUC0-12 (ng · h/ml)
|
||||
| Young women/young men | 98.1 | 75-128 | ||
| Elderly women/elderly men | 112 | 87-146 | ||
| Elderly/younga | 129 | 108-155 | ||
a
Male and female subjects combined.