TABLE 2.

Evaluation of glycopeptides tolerance in two S. lugdunensis isolates by time-kill curves and MBC/MIC ratios

Isolate	Time-kill curve					MBC/MIC ratioa
	Antibiotic concn	Variation in bacterial numbers (mean log CFU/ml) for:
		Vancomycin		Teicoplanin		Vancomycin	Teicoplanin
		6 h	24 h	6 h	24 h
S. lugdunensis 111A53, vancomycin-tolerant isolate	5× MIC	−0.05	−1.72	−0.33	−1.55	64, 8, >128	8, 32, >512
	10× MIC	−0.31	−1.94	−0.66	−3.77
	20× MIC	−0.07	−1.74	−0.23	−3.32
S. lugdunensis 111A91, teicoplanin-tolerant isolate	5× MIC	−1.16	−3.90	−0.29	−1.57	8, 1, 1	64, >512, 64
	10× MIC	−0.31	−3.53	−0.34	−2.26
	20× MIC	−0.56	−2.83	−0.47	−3.90

^aBoldface type indicates a tolerance phenomenon according to the criterion of each methodology. Ratios are in the order of first assay, second assay, third assay.