TABLE 2.
Antimicrobial and hemolytic activities of (RW)n-NH2 peptides
| Peptide | IC50 (μM)a
|
MBC50 (μM)a
|
HD50 (μM)ab
|
||
|---|---|---|---|---|---|
| E. coli | S. aureus | E. coli | S. aureus | Red blood cells | |
| RW-NH2 | 4.3 × 103 | 2.1 × 103 | 4.7 × 103 | 2.3 × 103 | 8.9 × 103 |
| (RW)2-NH2 | 7.3 × 102 | 2.1 × 102 | 9.9 × 102 | 6.2 × 102 | 3.7 × 103 |
| (RW)3-NH2 | 16 | 8.0 | 29 | 15 | 2.1 × 102 |
| (RW)4-NH2 | 9.6 | 5.1 | 14 | 12 | 1.0 × 102 |
| (RW)5-NH2 | 6.2 | 3.6 | 7.2 | 6.9 | 76 |
a
Results are the means of three independent experiments performed in parallel.
b
HD50 values determined from dose-response curves are peptide concentrations corresponding to 50% hemolysis.