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Pharmacokinetic parameters for four FQs, determined with uninfected BALB/c mice, following single ascending doses
| Drug | Dose range (mg/kg) | Cmax (μg/ml) | AUC0-∞ (μg · h/ml) | t1/2 value (h) |
|---|---|---|---|---|
| OFX | 37.5-2,400 | 1.7-101.2 | 29-661 | 4.93 ± 2.6 |
| MXF | 6-400 | 0.38-9.23 | 25-63 | 4.46 ± 0.66 |
| CIP | 37.5-2,400 | 1.2-31 | 29-125 | 4.74 ± 5.32 |
| SPX | 5-1,000 | 0.75-14 | 43-191 | 9.8 ± 5.32 |
