TABLE 2.
Comparison between groups of samples containing I84C, I84A, and I84V with similar backgroundsa
| Genotype at position:
|
Nb | Median (range) FC in resistance
|
RC (Nc) | Median RC (%) | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 46 | 54 | 84 | APV | IDV | LPV | NFV | RTV | SQV | |||
| M | I | V | 100 | 4.0 (1-400) | 2.4 (1-30) | 2.8 (1-174) | 4.0 (0.3-228) | 6.7 (2-400) | 4.3 (1-1,000) | 70 | 53 |
| M | I | C | 5 | 8.6 (2-53) | 4.1 (1-6) | 2.2 (0.4-5) | 74 (15-286) | 10 (2-29) | 56 (6-242) | 5 | 12 |
| I | I | V | 81 | 9.0 (1-91) | 9.1 (1-78) | 8.9 (1-162) | 9.0 (1-119) | 11 (2-82) | 4.3 (1-110) | 56 | 33 |
| I | I | A | 10 | 33 (21-252) | 73 (27-400) | 14 (9-94) | >600d (64-600) | 74 (34-167) | 261 (24-1,000) | 9 | 18 |
| IL | I | C | 6 | 21 (10-64) | 8.6 (4-63) | 3.1 (2-47) | 115 (51-600) | 18 (9-60) | 80 (24-1,000) | 5 | 13 |
| I | V | V | 51 | 36 (1-400) | 19 (1-400) | 80 (8-500) | 16 (2-129) | 49 (18-400) | 20 (1-1,000) | 38 | 27 |
| I | MV | A | 5 | 74 (30-400) | 178 (92-400) | 75 (50-211) | >600d (64-600) | >400d (141-400) | >1,000d | 4 | 19 |
a
Samples containing I84A, I84C, or I84V and the indicated changes at position 46 or 54 but no mutation at positions 30, 32, 48, 50, 82 (except 82I), and 90.
b
N, number of samples defined by mutation listed.
c
N, number of RC data.
d
The median FC for these groups was over the maximum measurable level of resistance; N, number of samples.