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Effects of mutations on RT activity in HIV-2 and HIV-1. Wild-type and mutated viruses were cultured as described in Materials and Methods. Histograms represent the maximal RT activity of mutated viruses expressed as a percentage of the values for wild-type controls. Error bars represent the mean ± the SEM of two independent experiments performed in duplicate. The HIV-2 viruses studied included CBL-20, CBL-23, and MVP-15132. The HIV-1 virus studied was isolate 5512.
