TABLE 3.
MICs and PAEs of nine S. pneumoniae strains
| Drug | MIC range (μg/ml) | PAE (h)a |
|---|---|---|
| LBM415 | 0.25-2.0 | 1.0 (0.3-1.4) |
| Amoxicillin-clavulanate | 0.03-4.0 | 1.0 (0.2-1.8) |
| Cefuroxime | 0.03-8.0 | 1.5 (1.0-2.5) |
| Cefdinir | 0.06-16 | 1.6 (1.0-3.2) |
| Ceftriaxone | 0.016-4.0 | 1.3 (0.5-2.0) |
| Imipenem | 0.008-0.25 | 1.7 (1.1-3.0) |
| Azithromycinb | 0.03-4.0 | 3.1 (1.8-5.0) |
| Clarithromycinb | 0.016-2.0 | 3.8 (2.3-6.0) |
| Levofloxacin | 1.0 | 1.3 (0.8-2.2) |
| Gatifloxacin | 0.25-0.5 | 1.7 (0.8-2.6) |
| Moxifloxacin | 0.125-0.25 | 1.5 (0.5-3.8) |
a
Data represent the means (ranges) of two experiments. The PAE was induced by 1 h of exposure at 10× MIC.
b
Three erythromycin-sensitive and three erythromycin-resistant mef(A) strains were tested.