TABLE 3.
HLA allelic associations with rubella virus vaccine-specific cytokine IL-10 responses
| Locus | Allelea | Allele count | IL-10 secretion value (pg/ml)
|
Allele P valueb | ||
|---|---|---|---|---|---|---|
| Median | First (lower) quartile | Third (upper) quartile | ||||
| All loci | All alleles | 212 | 291.04 | 197.84 | 355.59 | |
| HLA-A | *0101 | 34 | 282.33 | 196.28 | 392.48 | — |
| *0201 | 63 | 335.88 | 224.89 | 377.8 | 0.004 | |
| *0301 | 35 | 293.53 | 185.92 | 349.71 | — | |
| *1101 | 8 | 326.36 | 253.49 | 352.29 | — | |
| *2402 | 23 | 259.87 | 160.9 | 329.16 | — | |
| *2501 | 5 | 185.92 | 168.34 | 233.72 | — | |
| *3101 | 6 | 313.37 | 202.49 | 343.33 | — | |
| *3201 | 7 | 283.32 | 188.33 | 391.53 | — | |
| *6801 | 13 | 269.18 | 197.84 | 282.97 | 0.004 | |
| Other | 18 | 300.83 | 275.56 | 338.23 | — | |
| HLA-B | *0702 | 23 | 296.25 | 269.18 | 352.08 | — |
| *0801 | 22 | 280.36 | 193.36 | 374.61 | — | |
| *1302 | 6 | 266.83 | 112.96 | 369.29 | — | |
| *1501 | 20 | 299.22 | 195.6 | 363.29 | — | |
| *1801 | 7 | 271.53 | 168.34 | 293.79 | — | |
| *2705 | 10 | 278 | 202.49 | 374.61 | — | |
| *3501 | 9 | 267.37 | 212.75 | 361.24 | — | |
| *3801 | 7 | 329.16 | 258.1 | 377.8 | — | |
| *4001 | 14 | 300.15 | 271.62 | 344.49 | — | |
| *4402 | 25 | 262.84 | 193.88 | 343.33 | — | |
| *4403 | 9 | 289.06 | 260.88 | 305.41 | — | |
| *4901 | 7 | 403.42 | 338.1 | 447.18 | 0.004 | |
| *5101 | 6 | 338.27 | 305.62 | 392.48 | — | |
| *5501 | 5 | 278.38 | 193.88 | 283.32 | — | |
| *5701 | 5 | 282.33 | 167.87 | 403.42 | — | |
| Other | 37 | 288.09 | 185.92 | 335.88 | 0.06 | |
| HLA-Cw | *0102 | 9 | 374.61 | 333.22 | 458.65 | 0.06 |
| *0202 | 12 | 242.88 | 178.65 | 305.31 | — | |
| *0303 | 16 | 288.17 | 195.86 | 363.29 | — | |
| *0304 | 21 | 304.29 | 271.62 | 350.94 | — | |
| *0401 | 22 | 309.11 | 212.75 | 391.53 | — | |
| *0501 | 21 | 262.84 | 196.28 | 343.33 | — | |
| *0602 | 16 | 310.68 | 212.99 | 411.96 | — | |
| *0701 | 30 | 288.55 | 212.75 | 401.47 | 0.08 | |
| *0702 | 27 | 293.79 | 174.02 | 349.71 | — | |
| *0704 | 5 | 304.29 | 197.84 | 333.82 | — | |
| *1203 | 16 | 311.35 | 222.01 | 374.4 | — | |
| *1601 | 5 | 267.37 | 142.21 | 296.25 | — | |
| Other | 12 | 273.98 | 164.06 | 340.78 | — | |
| HLA-DRB1 | *0101 | 19 | 293.02 | 212.75 | 374.61 | — |
| *0301 | 24 | 280.36 | 191.94 | 361.73 | — | |
| *0401 | 23 | 275.56 | 168.34 | 355.59 | — | |
| *0404 | 8 | 324.95 | 265.11 | 350.72 | — | |
| *0701 | 22 | 246.8 | 154.81 | 296.25 | 0.07 | |
| *0801 | 6 | 248.28 | 145.45 | 269.18 | — | |
| *0901 | 5 | 352.08 | 196.28 | 374.57 | — | |
| *1101 | 10 | 332.52 | 215.6 | 391.53 | — | |
| *1104 | 5 | 370.99 | 271.53 | 424.53 | — | |
| *1201 | 5 | 224.89 | 188.33 | 288.09 | 0.10 | |
| *1301 | 18 | 284.55 | 193.88 | 329.16 | — | |
| *1302 | 11 | 344.49 | 282.97 | 429.63 | 0.03 | |
| *1401 | 6 | 319.05 | 293.79 | 392.48 | — | |
| *1501 | 22 | 294.78 | 271.53 | 352.08 | — | |
| Other | 28 | 312.07 | 205.9 | 392.75 | — | |
| HLA-DQB1 | *0201 | 27 | 278.38 | 188.33 | 348.85 | — |
| *0202 | 17 | 259.87 | 145.45 | 293.79 | 0.06 | |
| *0301 | 45 | 279.5 | 196.28 | 370.99 | — | |
| *0302 | 19 | 324.66 | 262.84 | 350.94 | — | |
| *0303 | 11 | 333.22 | 196.28 | 391.53 | — | |
| *0402 | 7 | 260.88 | 145.45 | 305.62 | — | |
| *0501 | 26 | 294.52 | 212.75 | 374.61 | — | |
| *0503 | 6 | 319.05 | 293.79 | 392.48 | — | |
| *0602 | 26 | 296.14 | 271.53 | 361.24 | — | |
| *0603 | 16 | 274.17 | 183.95 | 321.83 | — | |
| Other | 12 | 340.19 | 277.88 | 457.27 | 0.04 | |
| HLA-DPB1 | *0101 | 17 | 306.87 | 254.02 | 374.61 | — |
| *0201 | 21 | 293.79 | 215.6 | 399.09 | — | |
| *0301 | 16 | 333.22 | 290.94 | 347.1 | — | |
| *0401 | 91 | 288.09 | 193.36 | 355.59 | — | |
| *0402 | 29 | 275.56 | 193.88 | 370.99 | — | |
| *0601 | 5 | 282.97 | 254.02 | 344.49 | — | |
| Other | 33 | 289.06 | 197.84 | 352.08 | — | |
“Other” includes the following: HLA-A alleles *0102, *0202, *0205, *0206, *0207, *0302, *2301, *2403, *2601, *2608, *2902, *3001, *3002, *3206, *3301, *6601, *6802, *6803, and *6901; HLA-B alleles *0704, *0705, *0706, *0714, *1301, *1401, *1402, *1502, *1503, *1506, *1510, *1516, *1517, *1518, *1522, *1525, *1803, *2702, *3502, *3503, *3504, *3508, *3523, *3701, *3901, *3902, *3906, *4002, *4101, *4201, *4404, *4405, *4501, *4601, *4701, *4801, *4803, *5201, *5301, *5601, *5702, *5801, *5802, and *7301; HLA-Cw alleles *0302, *0403, *0406, *0604, *0706, *0710, *0712, *0801, *1202, *1402, *1502, *1505, *1602, *1604, *1701, *1703, and *1802; HLA-DRB1 alleles *0102, *0103, *0302, *0402, *0403, *0405, *0407,*0408, *0802, *0803, *0804, *1001, *1102, *1103, *1105, *1106, *1111, *1119, *1202, *1208, *1303, *1304, *1305, *1310, *1315, *1405, *1406, *1410, *1424, *1502, *1503, *1601, and *1602; HLA-DQB1 alleles *0203, *0304, *0306, *0502,*0601, *0604, *0608, *0609, and *0614; and HLA-DPB1 alleles *0501,*0901, *1001, *1101, *1301, *1401, *1501,*1601, 1701,*1901, *2001, *2101, *2301, *2401, *2601, *3001, *5001, *5101, *6301, and *6601.
Linear regression analysis was done to study allelic associations. Due to data skewness, P values were based in rank-transformed data. Analyses were adjusted for age at blood draw, gender, race, age at first MMR, and age at second MMR. P values of ≤0.05 are shown in bold. —, P values of >0.10 have been omitted. The global P values for HLA-A, HLA-B, HLA-Cw, HLA-DRB1, HLA-DQB1, and HLA-DPB1 loci were 0.29, 0.39, 0.54, 0.16, 0.13, and 0.85, respectively.