TABLE 1.
Twenty six nagt variants within known species complexes of Leishmania recognized by analyses of 193 independent isolatesa
| nagt genotypesb | WHO Codec | Diseased | nagt genotypesb | WHO Codec | Diseased | |
|---|---|---|---|---|---|---|
| L. amazonensis/mexicana | HOM/TN/90/FMH | CL | ||||
| complex (5)e | 13 Variant 5 (I/II) (1) | HOM/CN/99/Gansu-Wangg | VL | |||
| 1 L. amazonensis (1) | RAT/BR/72/LV78g | CL | ||||
| 2 Variant 6 (1) | HOM/CN/75/Kashi-BTO13 | VL | L. turanica/gerbilli | |||
| 3 Variant 17 (1) | HOM/CN/97/Gansu-LUO | VL | complex (21) | |||
| 4 L. mexicana (2) | HOM/CO/94/1182g | CL | 14 L. turanica (15) | RHO/CN/99/KMA2g | CL | |
| HOM/MX/84/ISTE GS | CL | RHO/CN/92/Qi Daig | CL | |||
| L. donovani/infantum | RHO/IR/04?/IR14 | CL | ||||
| complex (91) | 15 L. gerbilli (6) | RHO/CN/62/20g | CL | |||
| 5 L. infantum (63) | HOM/TR/00/OG-VLg | VL | IMON/CN/97/KMP3 | N/A | ||
| HOM/TR/03/Adana #7 | CL | |||||
| HOM/GR/70?/GH5 | CL | L. tropica complex (48) | ||||
| CANL/IR/04/IR2B | VL? | 16 L. tropica (I/II) (22) | HOM/TR/95/MACg | CL | ||
| HOM/FR/80/189 | VL? | HOM/SY/00/Am | CL | |||
| HOM/ES/81/260 | VL? | HOM/AZ/74/K27 | CL | |||
| HOM/CN/80/801 | VL | HOM/IQ/73/LRC L32 | CL | |||
| HOM/TN/90/DREP13 | CL | HOM/IR/94/X54 | CL | |||
| HOM/BR/82/BA-2, C1 | VL | HOM/SA/91/WR2044 | VL (asymptomatic) | |||
| 6 Variant 2 (15) | HOM/CN/50?/Bman | VL | HOM/JO/90-91?/Jh33 | CL | ||
| HOM/SD/03?/VL2 | VL | HOM/SU/60/BTO11 | CL | |||
| 7 Variant 4 (1) | HOM/KE/84/NLB323g | VL | HOM/KE/81/NLB 030Bg | VL | ||
| 8 Variant 7 (7) | HOM/CN/93/KXG-LIUg | CL | HOM/IN/76/UR6g | VL | ||
| IWUI/CN/87/KXG65 | N/A | 17 L. tropica (I/I) (9) | HOM/TR/04/EP94 | CL | ||
| HOM/CN/89/Shandong | VL | HOM/IR/03/IR1 | HIV-CL/VL | |||
| 9 L. donovani (5) | HOM/IN/96/JD | VL | CAN/IR/02/IR3C | VL ? | ||
| HOM/LK/03/H9 | CL | 18 Variant 2 (III/III) (7) | IROS/NA/87/8688g | N/A | ||
| L. major complex (23) | HOM/NA/84/K1 | CL | ||||
| 10 L. major (9) | HOM/IL/80/Friedling | CL | 19 Variant 2-1 (IV/IV) (1) | HOM/KE/84/NLB297Ag | ? | |
| HOM/TR/96/DK | CL | 20 Variant 6 (VII/VII) (6) | HOM/TR/03/EP82g | CL | ||
| HOM/EG/95/Dr. B | CL | 21 Variant 7 (V/V) (1) | HOM/IQ/91/WR1095g | VL (asymptomatic) | ||
| HOM/IR/??/IR173 | CL | 22 Variant 14 (IV/VI) (2) | HOM/KE/85/NLB545g | ? | ||
| HOM/EQ/87/G-09 | CL | L. braziliensis/panamensis (4) | ||||
| 11 Variant 1 (6) | HOM/TR/94/HKg | CL | 23 L. braziliensis (I/I) (1)f | HOM/BR/75/M2904g | CL | |
| HOM/IR/02/Iran 9 | CL | 24 Variant 4 (I/II) (1) | HOM/BR/75/M2903 | CL | ||
| HOM/IN/05?/RMP-240 | PKDL | 25 L. panamensis (2) | HOM/PA/71/LS94 | CL | ||
| 12 Variant 4 (I/I) (7) | HOM/TR/93/HA | VL | HOM/CO/00?/140 | CL | ||
| HOM/TR/93/SYg | CL | L. enriettii (1) | ||||
| HOM/IR/64/Iran8 | CL | 26 enriettii (1) | CAV/BR/45/enriettiig | CL | ||
| RHO/SD/02?/CL1 | CL |
Listed are 65 representatives of 77 sequenced.
Variant 1 to 17, the number of nucleotide substitutions against an arbitrarily selected reference sequence in each species complex. I to VII, different alleles in L. major, L. tropica, and L. braziliensis complex. Numbers in parentheses represent the actual number of isolates.
Host/reservoirs: CAN, dog (Canis familiaris); CANL, wolf (C. lupus pallipos); CAV, guinea pig (Cavia sp.); HOM, Homo sapiens; IMON, sand fly (Phlebotomus mongolensis); IROS, sand fly (P. rossi); IWUI, sand fly (P. major wui); RAT, Rattus rattus; RHO, great gerbil (Rhobomys opimus). Countries of origin: AZ, Azerbaijan; BR, Brazil; CN, China; CO, Colombia; EG, Egypt; EQ, Ecuador; ES, Spain; FR, France; GR, Greece; IL, Israel; IN, India; IQ, Iraq; IR, Iran; JO, Jordan; KE, Kenya; LK, Sri Lanka; MX, Mexico; NA, Namibia; PA, Panama; SA, Saudi Arabia; SD, Sudan; SU, Soviet Union; SY, Syria; TN, Tunisia; TR, Turkey. 45 to 05, year of isolation. ?, information not provided in writing by the donors.
PKDL, post-kala-azar dermal leishmaniasis; N/A, not applicable.
Numbers of isolates examined by RFLP analyses and/or sequencing.
Sequence obtained from GeneDB.
Strains used for sequencing the fc gene and other single-copy genes. fc gene sequences were also obtained from L. donovani (HOM/IN/00/IN0041J) and L. infantum variant 2 (HON/CN/90/901), which are not listed.