TABLE 2.
Statistical analysis of virulence data
| Type of strain | No. of mice | MTD in days (% surviving)a | P valueb |
|---|---|---|---|
| fox2 | |||
| Wild type (SC5314) | 21c | 4.8 | |
| fox2Δ (MRC6) | 20c | 6.9 | 0.0007 |
| fox2Δ + FOX2 (MRC5) | 22c | 3.8 | |
| Wild type | 10 | 4.4 | |
| fox2Δ (MRC8) | 10 | 8.4 | 0.008 |
| Wild type (105) | 10 | 17.4 | |
| fox2Δ (MRC6 [105]) | 10 | 45 (60) | 0.0015 |
| icl1 | |||
| Wild type (SC5314) | 10 | 4.2 | |
| icl1Δ (MRC10) | 10 | 20 (20) | 0.002 |
| icl1Δ + ICL1 (MRC11) | 10 | 2.7 | |
| fbp1 | |||
| Wild type (SC5314) | 10 | 5.2 | |
| fbp1Δ (MRC14) | 10 | 20 (10) | 0.0006 |
| fbp1Δ (MRC16) | 10 | 20 (30) | <0.0001 |
| fbp1Δ + FBP1 (MRC15) | 10 | 9.4 |
a
In several experiments, not all animals died. Values in parentheses represent the percentages of animals surviving at the end of the experiment.
b
P values are calculated compared to the wild-type strain used in that experiment using the log rank test (Prism3; Graphpad Software).
c
This experiment was repeated twice. The data are grouped here for convenience.