Table 1 Association between autoantibodies and measures of inflammation (CRP, sPLA₂, and the combination of CRP and sPLA₂) at different points in time.

	B (95% CI)
	CRP	sPLA2	CRP + sPLA2
IgM RF
Inflammation 3 years earlier	0.06 (−0.01 to 0.12)	0.07 (0.04 to 0.10)	0.18 (0.07 to 0.29)
Inflammation 2 years earlier	0.07 (0.01 to 0.13)	0.05 (0.02 to 0.08)	0.16 (0.06 to 0.25)
Inflammation 1 year earlier	0.12 (0.06 to 0.18)	0.05 (0.01 to 0.08)	0.19 (0.10 to 0.29)
Inflammation at same point in time	0.09 (0.04 to 0.13)	0.07 (0.04 to 0.09)	0.20 (0.13 to 0.27)
Inflammation 1 year later	0.06 (0.00 to 0.12)	0.04 (0.02 to 0.07)	0.15 (0.06 to 0.24)
Inflammation 2 years later	0.11 (0.05 to 0.16)	0.02 (−0.01 to 0.04)	0.14 (0.05 to 0.23)
Inflammation 3 years later	0.05 (−0.01 to 0.12)	0.02 (−0.01 to 0.05)	0.09 (−0.01 to 0.20)
Anti‐CCP
Inflammation 3 years earlier	0.05 (0.00 to 0.10)	−0.02 (−0.05 to 0.01)	0.00 (−0.09 to 0.09)
Inflammation 2 years earlier	0.03 (−0.03 to 0.08)	−0.01 (−0.03 to 0.02)	0.01 (−0.07 to 0.09)
Inflammation 1 year earlier	0.08 (0.03 to 0.13)	0.00 (−0.03 to 0.03)	0.08 (−0.01 to 0.16)
Inflammation at same point in time	0.05 (0.02 to 0.09)	0.05 (0.02 to 0.07)	0.13 (0.07 to 0.19)
Inflammation 1 year later	0.00 (−0.05 to 0.05)	0.01 (−0.02 to 0.03)	0.01 (−0.07 to 0.04)
Inflammation 2 years later	0.08 (0.03 to 0.14)	0.02 (0.00 to 0.05)	0.13 (0.04 to 0.21)
Inflammation 3 years later	0.06 (−0.01 to 0.13)	0.01 (−0.02 to 0.05)	0.09 (−0.01 to 0.19)