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| Variable | Before methotrexate | After methotrexate |
|---|---|---|
| Lymphocytes | ||
| Vmax | 20.7 (5.6) | 16.2 (6.0)* |
| Km | 40.7 (2.9) | 38.3 (3.6) |
| Erythrocytes | ||
| Vmax | 100.9 (31.7) | 111.3 (42.3) |
| Km | 43.9 (6.9) | 42.6 (5.5) |
Results are shown as mean (SD).
*p<0.05 for the effect of methotrexate. p>0.1 for other variables.
Vmax values expressed as nmol/min/mg protein; Km values expressed as μmol/l.
