Table 3 Short table of intraclonal diversification.

	‐‐CDR1‐‐	‐‐CDR2	‐‐CDR3
VH4‐30	GGSISSGSYY...	YIYYSGST...
J2_8	‐‐‐‐‐‐‐D‐‐...	FM‐‐‐‐‐M...	VRDLGLGSD
J2_12	‐D‐‐‐‐‐NF‐...	FM‐‐‐‐‐M...	VRDLGLGSD
	‐‐CDR1‐‐	‐‐CDR2‐‐	‐‐‐‐‐‐CDR3‐‐‐‐‐‐
VH1‐46:	GYTFTSYY	INPSGGST	................
Ro85:	‐‐‐‐‐‐H‐	‐‐‐R‐‐RP	ARVAGLAGHDNYYMDV
Ro89:	‐‐‐‐I‐HD	‐‐‐R‐‐RP	‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐
	‐‐CDR1‐‐	‐‐CDR2‐‐	‐‐‐‐‐‐‐‐‐‐‐CDR3‐‐‐‐‐‐‐‐‐‐‐
VH1‐8:	GYTFTSYD	MNPNSGNT	..........................
Ro101:	‐‐‐‐I‐H‐	ID‐‐‐‐K‐	ARDGKAISLTRGFHLSVEADYPGLDV
Ro151:	‐‐S‐ITH‐	‐D‐S‐‐K‐	‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐
	‐‐CDR1‐‐	FR2‐>‐‐CDR2‐‐	‐‐‐‐‐‐‐CDR3‐‐‐‐‐‐‐
VH3‐23:	GFTFSSYA	EWVSAISGSGGST	..................
Ro113:	‐‐‐‐‐‐‐‐	‐‐‐‐D‐‐‐‐‐‐‐‐	AKFQYYYGSRTPSNWFDP
Ro112:	‐‐S‐‐TFG	‐‐‐‐D‐‐‐‐‐‐‐‐	‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐
	‐‐‐CDR1‐‐‐	FR2‐>‐CDR2‐‐	‐‐‐‐CDR3‐‐‐‐
VH4‐30:	GGSISSGGYS	EWIGYIYHSGST	............
Ko152:	‐‐‐‐‐‐‐L‐‐	‐‐‐‐‐‐‐‐‐‐‐‐	ARGEGGSYDFDS
Ko155:	‐‐‐‐‐‐‐L‐‐	‐‐‐‐E‐N‐‐‐‐‐	‐‐‐‐‐‐‐‐‐‐‐‐
	‐‐CDR1‐‐	‐‐CDR2‐‐	‐‐‐‐‐CDR3‐‐‐‐‐
VH3‐23:	GFTFSSYA	ISGSGGST	..............
Scy07:	‐L‐‐‐T‐‐	‐R‐‐‐DR‐	AKGTHSGSFSELDS
Scy64:	‐‐‐‐‐D‐W	‐NKD‐SV‐	‐‐‐‐‐‐‐‐‐‐‐‐‐‐

Alignment of amino acid sequences of differently mutated offspring from six B lymphocyte clones of patients Nos 1, 4, 5, and 6 to their respective germline sequences. In the first line FR, CDR, and the respective amino acid positions are indicated. Amino acids that are identical to the germline sequence are symbolised by dashes.

CDR, complementarity determining region; FR, framework region.