Table 3 Allele frequencies of 3 MATN3 variants in sibling pairs with symptomatic osteoarthritis (The GARP study).
| Phenotype | SNP3* | SNP5* | SNP6* |
|---|---|---|---|
| Rotterdam study | |||
| Controls | 0.39 (829/523) | 0.014 (1526/22) | 0.21 (1217/329) |
| GARP study | |||
| Total† | 0.41 (445/307) | 0.013 (750/10) | 0.24 (583/179) |
| Hand OA | 0.41 (321/223) | 0.011 (542/6) | 0.24 (418/132) |
| DIP OA | 0.39 (198/128) | 0.012 (326/4) | 0.21 (262/70) |
| CMC1 OA | 0.45 (112/92) | 0.010 (204/2) | 0.29 (148/60)‡ |
*Frequencies of the minor alleles (n common allele/n minor allele); SNP3 (G>A), SNP5 (C>T), SNP6 (G>A).
†Subjects with familial osteoarthritis at multiple joint sites.
‡p⩽0.01 v controls (the Rotterdam sample); p values and standard errors were adjusted for family relationship by using robust standard errors.
CMC1, first carpometacarpal joint; DIP, distal interphalangeal joint; GARP, Genetics, Osteoarthritis and Progression study; OA, osteoarthritis; SNP, single nucleotide polymorphism.