Table 1 Histological and immunohistochemical characterisation of the inflamed synovium in 12 patients with RA at baseline and at week 14.

Variable	Baseline	Week 14	p Value
Lining layer thickness	2 (1–3)	1 (1–1.5)	0.010
Vascularity	2 (1–3)	1.25 (0.5–2.5)	0.064
Lymphoid aggregates	0.5 (0–3)	0 (0–1)	0.040
Inflammatory infiltration	1.5 (0–3)	1 (0–3)	0.254
Plasma cells	0 (0–2.5)	0.5 (0–2.5)	0.518
Polymorphonuclear cells	0 (0–1)	0 (0–15)	0.157
CD3+ T lymphocytes	1 (0–3)	1.5 (0–2)	1.000
CD4+ T lymphocytes	0.5 (0–2.5)	1 (0–1.5)	0.773
CD8+ T lymphocytes	1 (0–2.5)	1 (0–2.5)	0.732
CD20+ B lymphocytes	1.5 (0–3)	1.5 (0–2.5)	0.226
CD38+ plasma cells	1 (0–3)	1 (0–3)	1.000
Lining CD68+ macrophages	1 (0.5–2)	1 (0.5–2.5)	0.332
Sublining CD68+ macrophages	1 (0.5–3)	2 (0.5–3)	0.066
Lining CD163+ macrophages	1.5 (0.5–3)	1 (0.5–2.5)	0.524
Sublining CD163+ macrophages	1 (0–2)	1.25 (0–2.5)	0.021
CD1a+ dendritic cells	1 (0–2.5)	0.5 (0–3)	0.832
CD83+ dendritic cells	0 (0–3)	0 (0–2)	0.131
Lining ICAM‐1	2 (1–3)	2 (0.5–3)	0.590
Sublining ICAM‐1	0.5 (0–3)	1 (0–3)	0.798
Endothelial ICAM‐1	2 (1.5–3)	2.5 (0.5–3)	0.952
Endothelial E‐selectin	2 (2–3)	2 (0–3)	0.203
Lining VCAM‐1	1.5 (1–3)	1.5 (0–2.5)	0.298
Sublining VCAM‐1	0.5 (0–2)	0.5 (0–2)	0.831
Endothelial VCAM‐1	0 (0–1)	0 (0–0.5)	0.480
Intracellular citrullinated proteins	0 (0–2.5)	0 (0–3)	0.180
HC gp‐39	1 (0–2.5)	0 (0–2.5)	0.301
mAb 12A staining	0 (0–2)	0 (0–3)	0.276

The synovial features were scored semiquantitatively on a 0–3 scale (0 is the lowest score and 3 is the highest score) and data are represented as median (range). The p values were calculated with Wilcoxon's signed ranks test.