Table 4 Levels of tumour necrosis factor and tumour necrosis factor receptors 1 and 2 during crisis.

	TNF* (pg/ml)	TNFR1† (ng/ml)	TNFR2‡ (ng/ml)	Mutation
Patient 1	40	1.1	NR	T50M/N
Patient 2	29	0.4	NR	T50M/N
Patient 3	33	0.6	NR	T50M/N
Patient 4	27	0.7	1.8	C30S/N
Patient 5	24	1.2	NR	R92W
Patient 6	40	0.9	4	C30S/N
Patient 7	8.8	49	9.6	R92Q

NR, not reported; TNF, tumour necrosis factor; TNFR, tumour necrosis factor receptor.

*TNF during crisis (normal <13 pg/ml); †TNFR1 during crisis (normal 0.8–1.9 ng/ml); ‡TNFR2 during crisis (normal 2–6.6 mg/ml).