TABLE 1.
In vitro susceptibilities of filamentous fungi isolated during 2000 and 2001
| Species (no. of isolates tested) | Antifungal agent | MIC or MECa (μg/ml)
|
MIC or MECa range (μg/ml) | % Total at ≤1 μg/ml | |
|---|---|---|---|---|---|
| 50% | 90% | ||||
| A. fumigatus (256) | Amphotericin | 1 | 1 | 0.5->8 | 96.1 |
| Caspofungin | 0.03 | 0.06 | 0.015-2 | 99.2 | |
| Itraconazole | 1 | 2 | 0.12-2 | 87.1 | |
| Posaconazole | 0.25 | 0.5 | 0.03-2 | 99.6 | |
| Ravuconazole | 0.25 | 0.5 | 0.06-2 | 98.8 | |
| Voriconazole | 0.25 | 0.5 | 0.06-4 | 98.8 | |
| A. flavus (30) | Amphotericin | 1 | 2 | 1-2 | 70.0 |
| Caspofungin | 0.03 | 0.06 | 0.015-0.12 | 100 | |
| Itraconazole | 0.5 | 1 | 0.25-2 | 96.7 | |
| Posaconazole | 0.25 | 0.5 | 0.12-1 | 100 | |
| Ravuconazole | 0.5 | 1 | 0.06-1 | 100 | |
| Voriconazole | 0.5 | 1 | 0.12-1 | 100 | |
| A. niger (29) | Amphotericin | 1 | 1 | 0.25-1 | 100 |
| Caspofungin | 0.03 | 0.06 | 0.015-0.06 | 100 | |
| Itraconazole | 2 | 2 | 0.5-4 | 44.8 | |
| Posaconazole | 0.5 | 1 | 0.25-1 | 100 | |
| Ravuconazole | 0.5 | 2 | 0.25-2 | 86.2 | |
| Voriconazole | 1 | 2 | 0.12-4 | 65.5 | |
| A. versicolor (20) | Amphotericin | 1 | 2 | 1-2 | 80.0 |
| Caspofungin | 0.03 | 0.12 | 0.015-4 | 90.5 | |
| Itraconazole | 1 | 2 | 0.12-2 | 65.0 | |
| Posaconazole | 0.5 | 1 | 0.06-2 | 90.0 | |
| Ravuconazole | 0.25 | 1 | 0.03-2 | 95.2 | |
| Voriconazole | 0.5 | 1 | 0.06-2 | 95.0 | |
| A. terreus (16) | Amphotericin | 2 | 2 | 1-4 | 37.5 |
| Caspofungin | 0.03 | 0.06 | 0.015-0.12 | 100 | |
| Itraconazole | 0.5 | 0.5 | 0.25-1 | 100 | |
| Posaconazole | 0.12 | 0.25 | 0.06-0.25 | 100 | |
| Ravuconazole | 0.25 | 0.5 | 0.03-0.5 | 100 | |
| Voriconazole | 0.25 | 1 | 0.06-0.5 | 100 | |
| Penicillium spp. (35) | Amphotericin | 1 | 2 | 0.12-2 | 85.7 |
| Caspofungin | 0.03 | 0.12 | 0.015->8 | 97.4 | |
| Itraconazole | 1 | 2 | 0.25-2 | 77.1 | |
| Posaconazole | 0.5 | 1 | 0.06-2 | 97.1 | |
| Ravuconazole | 0.5 | 4 | 0.015-8 | 80.0 | |
| Voriconazole | 0.5 | 2 | 0.03->8 | 80.0 | |
| Fusarium spp. (11) | Amphotericin | 1 | 2 | 1-2 | 81.8 |
| Caspofungin | >8 | >8 | >8->8 | 0 | |
| Itraconazole | >8 | >8 | 2->8 | 0 | |
| Posaconazole | >8 | >8 | 0.5->8 | 18.2 | |
| Ravuconazole | 8 | >8 | 0.25->8 | 18.2 | |
| Voriconazole | 4 | >8 | 0.25->8 | 18.2 | |
| Paecilomyces spp. (6) | Amphotericin | 0.5 | 0.06->8 | 66.7 | |
| Caspofungin | 0.06 | 0.03-8 | 83.3 | ||
| Itraconazole | 0.25 | 0.06-2 | 83.3 | ||
| Posaconazole | 0.12 | 0.03-0.5 | 100 | ||
| Ravuconazole | 0.25 | 0.03-4 | 83.3 | ||
| Voriconazole | 0.25 | 0.03-2 | 83.3 | ||
| Rhizopus spp. (5) | Amphotericin | 1 | 0.5-1 | 100 | |
| Caspofungin | >8 | >8->8 | 0 | ||
| Itraconazole | 4 | 1->8 | 20 | ||
| Posaconazole | 2 | 1-4 | 40 | ||
| Ravuconazole | >8 | 0.5->8 | 20 | ||
| Voriconazole | 2 | 1->8 | 40 | ||
| Mucor spp. (3) | Amphotericin | 0.5 | 0.5-1 | 100 | |
| Caspofungin | >8 | >8->8 | 0 | ||
| Itraconazole | 2 | 2->8 | 0 | ||
| Posaconazole | 1 | 0.5->8 | 66.7 | ||
| Ravuconazole | >8 | 1->8 | 33.3 | ||
| Voriconazole | 2 | 1->8 | 33.3 | ||
| All Aspergillus (372) | Amphotericin | 1 | 1 | 0.12->8 | 90.6 |
| Caspofungin | 0.03 | 0.06 | 0.015-4 | 98.4 | |
| Itraconazole | 1 | 2 | 0.12->8 | 83.1 | |
| Posaconazole | 0.25 | 0.5 | 0.03->8 | 98.1 | |
| Ravuconazole | 0.25 | 1 | 0.03->8 | 96.8 | |
| Voriconazole | 0.5 | 1 | 0.03->8 | 95.2 | |
| All filamentous fungi (448) | Amphotericin | 1.0 | 2.0 | 0.06->8 | 89.3 |
| Caspofungin | 0.03 | 0.12 | 0.015->8 | 92.8 | |
| Itraconazole | 1.0 | 2.0 | 0.06->8 | 79.0 | |
| Posaconazole | 0.25 | 1.0 | 0.03->8 | 94.6 | |
| Ravuconazole | 0.25 | 1.0 | 0.015->8 | 91.3 | |
| Voriconazole | 0.5 | 1.0 | 0.03->8 | 90.2 | |