Table 2 Summary of the loci identified from the affected sibling pair analyses.
| Chromosome | cM | LODmax* | p Value | Span | Stratification | Reference |
|---|---|---|---|---|---|---|
| 4 | 25.9 | 1.34 | 0.007 | 20.8–36.6 | Nodal+x ray | |
| 36.1 | 0.8 | 0.03 | 31.2–37.7 | Nodal OA | ||
| 57.0 | 0.65 | 0.04 | 53.7–58.8 | Nodal OA | ||
| 7 | 135.9 | 0.92 | 0.02 | 130.4–141.6 | Nodal OA | Chapman et al30 |
| 137.8 | 0.77 | 0.03 | 137.2–139.7 | Nodal+x ray | Chapman et al30 | |
| 11 | 116.0 | 1.63 | 0.003 | 98.4–126.8 | Nodal OA | |
| 118.5 | 2.69 | <0.000 | 99.0–141.9 | Nodal+x ray | ||
| 22 | 27.4 | 1.51 | 0.004 | 14.4–41.7 | Nodal+x ray |
LODmax, maximum logarithm of the odds of linkage; OA, osteoarthritis.
*Correction for the six models tested requires the subtraction of LOD 0.30 from these values.
The highest LOD (LODmax) at each locus is shown with the corresponding cM position (Marshfield). The span indicates the extent of the region of nominal significance. Published studies on osteoarthritis linkage that have identified loci on which the position of maximal linkage is within 10 cM of the LODmax given here are referenced.