Table 3 Summary of the loci identified from the quantitative analyses.

Chromosome	cM	LODmax*	p Value	Span	Trait index	Reference
2	103.7	1.04	0.014	103.2	DIP
3	91.2	2.5	<0.003	80.3–97.8	U‐OST, OST, U‐JSN	Stefansson et al,18 Chapman et al30
	109.2	1.32	0.007	109.2	JSN
	146.6	1.33	0.007	146.6	DIP, U‐DIP
	214.5	1.67	0.003	214.5–224.9	JSN
4	36.1	1.95	0.0013	25.9–69.5	JSN
	57.0	2.95	0.0011	25.9–69.5	JSN, U‐JSN
5	28.8	1.23	0.009	26.7–28.8	OST
	179.1	1.57	0.004	179.1	JSN
	194.9	1.29	0.007	194.9	DIP, U‐OST
6	89.8	1.11	0.012	82.6–109.2	U‐OST	Stefansson et al18
7	137.8	1.53	0.004	137.8	OST	Chapman et al30
8	8.3	1.57	0.004	8.3–21.3	JSN
	60.9	2.56	<0.003	41.5–79.4	U‐DIP
	111.7	1.12	0.012	111.7–112.4	U‐JSN	Leppavuori et al16
11	112.3	1.64	0.003	108.6–123.0	DIP
	118.5	1.45	0.005	105.7–118.5	JSN, U‐JSN
12	75.2	0.94	0.02	75.2	OST
13	17.2	1.28	0.008	17.2–25.1	OST	Demissie et al20
	93.5	1.13	0.011	93.5	DIP	Demissie et al20
14	40.1	1.44	0.005	40.1–47.5	U‐DIP
	69.2	1.17	0.01	69.2–76.3	U‐JSN
16	52.3	2.64	<0.002	48.5–57.8	U‐JSN	Ingvarsson et al,31 Forster et al32
18	71.3	1.34	0.007	71.3–84.8	OST
19	72.7	1.25	0.008	72.7	JSN	Demissie et al20
20	11.2	1.15	0.011	11.2	OST
	50.8	2.2	<0.007	39.3–61.8	OST
	75.0	1.36	0.006	75.0	OST
X	23.3	1.04	0.014	23.3	JSN
	42.2	1.05	0.014	42.2–52.5	OST	Leppavuori et al,16 Chapman et al30

DIP, distal interphalangeal; JSN, joint‐space narrowing; LODmax, maximum logarithm of the odds of linkage; OST, osteophyte; U‐DIP, unaffected distal interphalangeal; U‐JSN, unaffected joint‐space narrowing; U‐OST, unaffected osteophyte.

*Correction for the six models tested requires the subtraction of LOD 0.78 from these values.

The highest LOD (LODmax) at each locus is shown with the corresponding cM position (Marshfield). The span indicates the extent of the region of nominal significance. Published studies on osteoarthritis linkage that have identified loci where the position of maximal linkage is within 10 cM of the LODmax given here are referred to.