Table 2 Responsiveness of individual items and indices ranked by t value in the Infliximab Multinational Psoriatic Arthritis Controlled Trial.
| Active drug | Placebo | t Value | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Baseline | Mean Δ | SEΔ | SRM | ES | Baseline | Mean Δ | SEΔ | SRM | ES | ||
| GST | – | 460 | 16.2 | 3.96 | – | – | 226 | 14.9 | 2.15 | – | 10.6 |
| DAS28 (0–10) | 5.5 | −2.6 | 0.2 | −1.87 | −2.30 | 5.4 | −0.2 | 0.1 | −0.21 | −0.20 | 9.8 |
| PhGA (0–100) | 53.6 | −33.9 | 3.2 | −1.49 | −1.84 | 52.4 | 0.3 | 2.4 | 0.02 | 0.01 | 8.5 |
| DAS (0–10) | 4.1 | −1.9 | 0.2 | −1.77 | −2.13 | 3.9 | −0.1 | 0.2 | −0.13 | −0.15 | 8.2 |
| Pain (0–100) | 53.4 | −31.1 | 3.1 | −1.40 | −1.46 | 56.0 | −0.1 | 2.8 | −0.01 | 0.00 | 7.3 |
| PtGA (0–100) | 52.4 | −27.6 | 3.2 | −1.21 | −1.18 | 56.0 | 1.0 | 3.1 | 0.05 | 0.05 | 6.4 |
| TJC68 (0–68) | 23.7 | −13.1 | 1.6 | −1.14 | −0.96 | 20.4 | 0.8 | 1.7 | 0.07 | 0.07 | 6.0 |
| ESR (mm/h) | 32.7 | −24.3 | 2.8 | −1.24 | −1.10 | 29.5 | −4.6 | 1.9 | −0.34 | −0.24 | 5.7 |
| TJC28 (0–28) | 10.6 | −6.2 | 0.7 | −1.14 | −0.98 | 9.7 | −0.11 | 0.8 | −0.02 | −0.02 | 5.4 |
| MS (min) | 125.8 | −91.5 | 21.9 | −0.59 | −0.59 | 149.9 | −24.1 | 28.1 | −0.12 | −0.09 | 5.0 |
| SJC66 (0–66) | 14.6 | −9.7 | 1.2 | −1.15 | −1.27 | 14.7 | −1.0 | 1.3 | −0.11 | −0.14 | 5.0 |
| HAQ (0–3) | 1.15 | −0.56 | 0.07 | −1.18 | −0.79 | 1.18 | −0.01 | 0.04 | −0.03 | −0.01 | 4.8 |
| SJC44 (0–44) | 11.9 | −7.7 | 1.0 | −1.08 | −1.26 | 11.7 | −1.0 | 1.1 | −0.13 | −0.14 | 4.7 |
| RAI (0–75) | 13.5 | −6.7 | 0.8 | −1.19 | −0.86 | 11.8 | −0.2 | 1.3 | −0.02 | −0.02 | 4.3 |
| SJC28 (0–28) | 8.7 | −5.7 | 0.9 | −0.93 | −1.13 | 9.1 | −1.3 | 0.8 | −0.21 | −0.23 | 3.8 |
| PASI (0–72) | 5.1 | −4.1 | 0.8 | −0.82 | −0.69 | 4.2 | 0.6 | 0.4 | 0.22 | 0.11 | 2.6 |
| CRP (mg/l) | 21.7 | −11.3 | 3.4 | −0.61 | −0.57 | 31.1 | −8.9 | 3.3 | −0.40 | −0.37 | 0.6 |
CRP, C reactive protein; DAS, Disease Activity Score; ES, effect size; ESR, erythrocyte sedimentation rate; GST, global statistical test; HAQ, Health Assessment Questionnaire; Mean Δ, mean change; MS, morning stiffness; PASI, Psoriasis Area and Severity Index; PhGA, physician global assessment; PtGA, patient global assessment; RAI, Ritchie Articular Index; SEΔ, standard error of mean change; SJC, swollen joint count; SRM, standardised response mean; TJC, tender joint count.