Table 4 Discriminative capacity of response criteria.
IMPACT | Placebo (n = 52) | Active drug (n = 52) | χ2MH | p Value |
---|---|---|---|---|
Response criteria | % improved | % improved | ||
EULAR28 | 53.4 | <0.001 | ||
Good+moderate | 26 | 92% | ||
Good | 0 | 60 | ||
EULAR | 48.6 | <0.001 | ||
Good+moderate | 26 | 88 | ||
Good | 0 | 63 | ||
ACR20 | 10 | 67 | 36.2 | <0.001 |
ACR50 | 0 | 48 | 32.6 | <0.001 |
ACR70 | 0 | 29 | 17.4 | <0.001 |
PsARC | 30 | 82 | 27.9 | <0.001 |
ΔDAS28>1.2 | 13 | 83 | 49.4 | <0.001 |
ΔDAS>1.2 | 10 | 67 | 36.2 | <0.001 |
Low‐disease activity criteria | % reached | % reached | χ2MH | p Value |
DAS28⩽3.2 | 4 | 61 | 35.3 | <0.001 |
DAS⩽2.4 | 8 | 65 | 33.4 | <0.001 |
OMERACT MDAS | 6 | 50 | 25.1 | <0.001 |
DAS28⩽2.6 | 2 | 41 | 21.2 | <0.001 |
DAS⩽1.6 | 0 | 35 | 20.0 | <0.001 |
Etanercept | Placebo (n = 30) | Active drug (n = 30) | χ2MH | p Value |
---|---|---|---|---|
Response criteria | % improved | % improved | ||
EULAR28 | 26.2 | <0.001 | ||
Good+moderate | 15 | 93 | ||
Good | 8 | 59 | ||
EULAR | 24.1 | <0.001 | ||
Good+moderate | 19 | 89 | ||
Good | 4 | 44 | ||
ACR20 | 15 | 73 | 19.6 | <0.001 |
ACR50 | 4 | 50 | 14.8 | 0.001 |
ACR70 | 0 | 13 | 3.8 | 0.05 |
PsARC | 33 | 90 | 19.3 | <0.001 |
ΔDAS28>1.2 | 7 | 80 | 32.2 | <0.001 |
ΔDAS>1.2 | 7 | 60 | 18.9 | <0.001 |
Low‐disease activity criteria | % reached | % reached | χ2MH | p Value |
DAS28⩽3.2 | 11 | 69 | 19.0 | <0.001 |
DAS⩽2.4 | 15 | 69 | 16.4 | <0.001 |
OMERACT MDAS | 7 | 63 | 20.8 | <0.001 |
DAS28⩽2.6 | 11 | 59 | 13.5 | 0.002 |
DAS⩽1.6 | 4 | 45 | 12.4 | 0.004 |
ACR, American College of Rheumatology; DAS, Disease Activity Score; EULAR, European League Against Rheumatism; IMPACT, Infliximab Multinational Psoriatic Arthritis Controlled Trial; MDAS, minimal disease activity in rheumatoid arthritis; OMERACT, Outcome Measures in Rheumatoid Arthritis Clinical Trials; PsARC, psoriatic arthritis response criteria; χ2MH, χ2 Mantel Haenszel.