TABLE 2.

Characteristics of selected antigens

Antigen no.	Gene	Rv no.a	Mol wt	Protein	Homology (%) in M. aviumb	Functionc	Commentsd
1		3872	9,911	TB9.9	28	Member of PE family	RD1 region
2		3873	37,318	TB37.6	32	Member of PPE family	RD1 region
3	lhp	3874	10,780	CFP-10	24	Unknown	RD1 region
4	esat-6	3875	9,889	ESAT-6	29	Unknown	RD1 region
5		3878	27,383	TB27.4	24	Unknown	RD1 region
6		1982	14,709	TB14.7	25	Belongs to UPF0110 family	RD2 region
7		1988	19,559	TB19.6	31	Methyltransferase	RD2 region
8		1573	14,564	TB14.6	30	Probable phage phiRv1 protein	RD3 region
9		1575	12,365	TB12.4	34	Probable phage phiRV1 protein	RD3 region
10		1579	11,186	TB11.2	34	Probable phage phiRv1 protein	RD3 region
11		1580	9,734	TB9.7	26	Probably phage phiRv1 protein	RD3 region
12		1582	52,402	TB52.4	14	Probable phage phiRv1 protein	RD3 region
13		1584	7,980	TB8	35	Unknown	RD3 region
14		1585	19,198	TB19.2	27	Possible phage phiRv1 protein	RD3 region
15		1586	51,717	TB51.7	27	Probable phiRv1 integrase	RD3 region
16		2660	7,533	TB7.6	35	Unknown	RD13 region
17		64	107,379	TB107.4	51	Possible membrane protein	Secreted protein
18		398	21,642	TB21.7	58	Possible exported protein	Secreted protein
19	mmpL4	450	105,223	TB105.2	65	Transmembrane protein	Secreted protein
20		559	12,103	TB12.1	54	Possible N-terminal signal sequence	Secreted protein
21		569	9,508	TB9.52	31	Unknown	Secreted protein
22		617	13,921	TB13.94	30	Unknown	Secreted protein
23		1242	15,858	TB15.87	24	Unknown	Secreted protein
24		1352	12,834	TB12.9	43	Unknown	Secreted protein
25	hspX	2031	16,218	TB16.2	28	Heat shock protein	Secreted protein
26		2253	17,822	TB17.8	23	Possible secreted protein	Secreted protein
27		2576	15,745	TB15.8	54	Unknown	Secreted protein
28		288	10,374	TB10.4	79	Unknown	ESAT-6 fam

^aThe M. tuberculosis gene numbering was used (11).

^bTBlastN was used with a blosum 62 scoring matrix. To allow homology searches in regions of low compositional complexity, searches were done without any filter.

^cFrom http://www.genolist.pasteur.fr/TubercuList. Proteins in the PE and PPE families share the Pro-Glu (PE) or Pro-Pra-Glu (PPE) motifs at positions 8 and 9 or 8 to 10, respectively.

^dRD numbering as in reference 4.