Figure 3. Stereo diagrams of metal-binding sites (a) and active site (b) in FAH.

(a) Stereo diagram of the metal-binding sites in FAH. The catalytic Mn²⁺ ion to which the FAH inhibitor 1 is bound is coloured yellow and the structural sodium ion is coloured green. (b) Stereo diagram of the active site in FAH. A stereo diagram of the active site is shown with Mn²⁺ coloured yellow and C, N and O coloured grey, blue and red respectively. A 2F_o–F_c electron density map for the FAH inhibitor 1 and Mn²⁺ is contoured in purple at a level of 2σ. Broken lines indicate important hydrogen bonds that stabilize the complex.