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. 2007 Feb 12;402(Pt 2):219–227. doi: 10.1042/BJ20061386

Figure 7. Amelioration of oxidative stress, anaemia and autoantibody production in SOD1−/− mice by NAC treatment for 20 weeks.

Figure 7

(A) Treatment with NAC suppressed intracellular ROS in RBCs as judged by FACS. (B) Treatment with NAC ameliorated anaemia (n=10–12). (C) Treatment with NAC ameliorated splenomegaly and thymus degeneration. Comparison of the weights of the spleen and thymus in SOD1−/− mice with or without NAC treatment. Relative ratios (%) to values of control mice without NAC treatment are shown. (D) Treatment with NAC decreased levels of bound IgG to erythrocytes. (E) Treatment with NAC decreased the plasma level of the antibody against CAII.