Table 2 Characteristics of muscle biopsy specimens of 15 patients with anti‐signal recognition particle autoantibodies.
| Patient | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | |
| Age | 48 | 32 | 31 | 38 | 53 | 56 | 61 | 55 | 33 | 57 | 63 | 44 | 40 | 47 | 62 |
| Sex | M | F | F | F | F | F | M | M | F | F | F | M | F | F | F |
| Country | GR | GR | GR | GR | GR | NL | NL | NL | NL | NL | NL | S | S | CZ | CZ |
| Necrotic fibres | +++ | + | − | ++ | + | ++ | ++ | ++ | + | ++ | +++ | + | − | − | − |
| Necrotic fibres with myophagia | +++ | − | − | ++ | − | + | − | + | − | + | ++ | + | − | − | − |
| Basophilic fibres | +++ | − | + | − | ++ | ++ | ++ | ++ | + | +++ | +++ | ++ | − | − | − |
| Swollen nuclei | + | ND | + | ND | + | + | +++ | + | − | ++ | +++ | − | − | + | + |
| Swollen capillaries | + | ND | + | ND | + | ++ | +++ | + | + | ++ | ++ | − | − | + | + |
| Pipe stem capillaries | − | − | − | − | − | − | − | − | − | − | − | − | − | − | − |
| % Internal nuclei | 10 | 0 | 16 | 3 | 2 | 2 | 8 | 13 | 15 | 9 | 3 | 21 | 4 | 4 | 1 |
| Fibre splitting | − | − | + | − | − | − | − | + | − | − | + | − | − | − | − |
| Atrophic fibres | +++ | − | − | + | +++ | ++ | ++ | + | + | ++ | +++ | + | + | − | + |
| Hypertrophic fibres | +++ | − | + | ++ | + | − | + | ++ | + | + | − | + | + | + | + |
| Endomysial fibrosis | + | − | − | − | − | − | − | − | − | − | + | − | − | − | − |
| Cellular infiltration | − | + | − | − | + | + | − | − | − | − | − | − | + | − | − |
| CD8 | ND | ND | ND | ND | ND | − | − | + | − | − | ++ | ND | ND | ND | ND |
| CD68 | ND | ND | ND | ND | ND | + | − | ++ | − | − | +++ | ND | ND | ND | ND |
| MAC | ND | ND | ND | ND | ND | + | − | ++ | + | − | +++ | ND | ND | ND | ND |
| Sarcolemmal HLA‐ABC | ND | ND | ND | ND | ND | − | − | − | − | − | − | ND | ND | ND | ND |
CZ, Czech Republic; F, female; GR, Greece; HLA, human leucocyte antigen; M, male; MAC, membrane attack complex; ND, not done or not measured; NL, The Netherlands; S, Sweden; −, normal or not present; +, slightly increased; ++, moderately increased; +++, very increased.