Table 1 Frequency distribution of HLA‐DRB1*04 alleles and shared epitope positive (SE+) genotypes (DRB1*0101/2, *0401/4/5/8/9, *1001) among Portuguese patients with rheumatoid arthritis and controls.
| Genotype | RA number (%) n = 141 | Control number (%) n = 150 | Odds ratio (95% CI) | p Value |
|---|---|---|---|---|
| DRB1*0101/02 | 38 (14.9) | 30 (11.3) | 1.48 (0.9 to 2.6) | NS |
| DRB1*04 | 63 (25.2) | 26 (9.7) | ||
| *0401 | 24 (8.9) | 4 (1.3) | 7.5 (2.5 to 22.2) | <0.001 |
| *0402 | 7 (2.5) | 5 (1.7) | NS | |
| *0403 | 4 (1.4) | 2 (0.7) | NS | |
| *0404 | 14 (5.0) | 5 (1.7) | 3.2 (1.1 to 9.1) | 0.03 |
| *0405 | 18 (6.4) | 10 (3.3) | NS | |
| *0406 | 0 | 1 (0.3) | NS | |
| *0407 | 0 | 1 (0.3) | NS | |
| *0408 | 2 (0.7) | 0 | NS | |
| *0409 | 1 (0.3) | 1 (0.3) | NS | |
| DRB1*0401/4/5/8/9 | 56 (21.3) | 18 (6.7) | 4.8 (2.7 to 8.8) | <0.001 |
| DRB1*0402/3/6/7 | 7 (3.9) | 8 (3, 0) | NS | |
| DRB1*1001 | 17 (6.0) | 7 (2.3) | 2.8 (1.1 to 7.0) | 0.031 |
OR, odds ratio; RA, rheumatoid arthritis.