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. 2003 Jul 8;4:5. doi: 10.1186/1471-2091-4-5

Table 2.

Comparison of variable region of protease domain in serine proteases

Protease Constant region 1 Variable region Constant region 2
tPA PWQAAI FAKHRRSPGERF LCGG
uPA PWFAAI YRRHRGGSVTY VCGG
Plasmin PWQVSL RTRFGMH FCGG
Thrombin PWQVM FRKSPQEL LCGA

Alignments of the amino acids sequences of the first variable region and parts of the surrounding constant regions of the protease domain of tPA, uPA, plasmin and thrombin. In the variable region positively charged amino acid residues are underlined.