Figure 4.

Transmural concentration profiles generated by simulations for a representative artery with an intermediate neointimal thickness. The EVAc collar was prereleased for 7 days, the heparin fraction of the drug mixture was 0.375, and the resulting intima-to-media area ratio was 0.31. The profile at 2 hr was generated without a neointimal layer (model I, ■), and the profile at 2 weeks was generated with a neointimal layer of the final thickness measured in each artery (model II, ▵). The intimal and medial concentrations are estimated to be within the shaded region throughout the experiment.