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Proposed enzyme mechanism of PepA and LAP. The bicarbonate ion next to Arg-356 (numbering according to PepA) acts as a general base and accepts a proton from the metal-bridging water nucleophile. The proton is shuttled to the leaving peptide amino group to facilitate breakdown of the tetrahedral gem-diol intermediate. However, proton movements may not be unique. For example, water molecules may be involved in the proton transfer paths.
