Figure 3.—

Membrane topology prediction of the SLC45A2 protein using TMHMM (v. 2.0; http://www.cbs.dtu.dk/services/TMHMM-2.0/). The locations of the frameshift mutation (S36fs) associated with imperfect albino (S*AL) and the two missense mutations Y277C and L347M associated with Silver (S*S) in chicken are indicated by solid arrowheads. The A72D mutation associated with cinnamon (AL*C) in Japanese quail is marked with a shaded arrowhead. The missing amino acids in the SLC45A2 protein encoded by sex-linked imperfect albinism (AL*A) in Japanese quail are shaded. Abn.Spl., aberrant splicing.