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. 1999 Sep 28;96(20):11173–11177. doi: 10.1073/pnas.96.20.11173

Figure 3.

Figure 3

The suppression effects of nos. 4, 6, 8, and 10 DHEA derivatives on the DHT-induced AR transcriptional activity. CAT activity was determined in PC-3 cells transiently cotransfected with 1.5 μg of WtAR and 4.5 μg of MMTV-CAT. After a 24-h transfection, cells were cultured for an additional 24 h in the presence of 1 nM DHT and simultaneously treated with increasing concentrations of various DHEA derivatives. The leftmost bar shows the activity of DHT alone (set as 100%). Values represent the means ± SD of at least three determinations.