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Distribution of total disease allele frequency: ne and f0 at each DSL of polygenic diseases. N = 104 (a) or 105 (b); μ = 10−5; k = 200; and s = 0, 0.5 × 10−4, 10−4, 0.5 × 10−3 (from top to bottom). Solid curves are densities given by Equation 8. Dashed lines are estimated effective number of alleles. The mean f0 of all DSL at the last generation is used to estimate μS and μN.
