Figure 4.—

Structure of the mouse and human Tapt1 genes. The genomic structures of mouse Tapt1 (4932414K18Rik) and human Tapt1 (FLJ90013), as represented in the University of California at Santa Cruz (UCSC) Genome Browser as of April 2006 are shown, as are three human mRNAs from GenBank. The AF189251 mRNA was reported to encode the HCMV gH receptor (Baldwin et al. 2000). Exons are represented by vertical bars along the horizontal lines and are numbered. Transcription is to the left, toward the centromere in both species. The location of the L5Jcs1 mutation, distal to exon 7, is indicated by a vertical red bar/ball. The lines drawn between the human and mouse genes connect orthologous exons. (Bottom) A depiction of conservation between the mouse sequence and other vertebrates, as displayed by the indicated UCSC browser track. The red arrow indicates the location of a highly conserved region that corresponds to an alternative exon included in some ESTs (not shown).