TABLE 1.
Allele | Surface expression (% of cells)
|
||||
---|---|---|---|---|---|
Murine
|
Human
|
||||
3T3 | Ba/F3 | 293T | K562 | TF-1 | |
MIG | 0.3 | 0.2 | 0.3 | 0.2 | 19.3 |
hKITWT | 82.5 | 94.9 | 97.8 | 86.0 | 73.2 |
hKITD816V | 3.6 | 5.9 | 79.0 | 49.2 | 50.6 |
HyKITWT | 99.4 | 87.1 | 98.6 | 93.5 | 79.6 |
HyKITD816V | 30.4 | 35.5 | 66.8 | 49.3 | 55.0 |
mKitD814V | 49.8 | 36.4 | 87.8 | 57.8 | 61.3 |
A variety of murine and human cell lines were transduced with KIT alleles, and KIT receptor surface expression was assessed by flow cytometry.