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. 2006 Oct 9;27(1):220–228. doi: 10.1128/MCB.00899-06

FIG. 5.

FIG. 5.

The A-loop of the ErbB2 kinase domain adopts a different conformation from that of ErbB1. (a) Sequence alignment of the A-loops of ErbB1 and ErbB2. Identical residues are indicated by a vertical bar, and similarity is indicated by a dot. Asterisks indicate the phosphorylated tyrosine residues. Panels b, c, d, and e are conformations of the A-loops of ErbB1 and ErbB2 in the unphosphorylated and phosphorylated states, respectively. Green dotted lines indicate salt bridges or hydrogen bonds. (f) Superimposition of the modeled structures of the ErbB2 kinase domain with the A-loop in the phosphorylated or unphosphorylated states. Red denotes the unphosphorylated A-loop, and blue denotes the phosphorylated A-loop.