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Adenovirus-mediated gene transfer in the skin
| Injection size and mouse genotypea | No. of mice injected with:
|
||
|---|---|---|---|
| Ad-Control | Ad-fbln5 | Ad-fbln5 Δ1 | |
| Low titerb (5 × 108 PFU/mouse) | |||
| KO | 5 | 8 | 5 |
| Het | 2 | 0 | 4 |
| High titerc (1011 particles/mouse) | |||
| KO | 6 | 5 | 4 |
| Het | 2 | 3 | 3 |
KO, fbln5−/−; Het, heterozygous.
Empty adenovirus (Ad-RR5) was used as a control in low-titer experiments.
Adenovirus encoding β-Gal (Ad-β-gal) was used as a control in high-titer experiments.
