TABLE 1.
B-cell numbers in bone marrow and spleen in Cd19Cre/+ Mapk1+/+ and Cd19Cre/+ Mapk1flox/flox mice
| Cells | No. (106)b in:
|
|
|---|---|---|
| Cd19Cre/+Mapk1+/+ mice | Cd19Cre/+Mapk1flox/flox mice | |
| Bone marrowa | ||
| Pro B (B220lo IgM− CD43+) | 0.206 ± 0.042 | 0.359 ± 0.119 |
| Pre B (B220lo IgM− CD43−) | 1.987 ± 0.859 | 2.112 ± 0.529 |
| Immature B (B220lo IgM+) | 0.935 ± 0.217 | 1.258 ± 0.506 |
| Recirculating B (B220hi IgM+) | 0.722 ± 0.213 | 1.670 ± 0.860 |
| Spleen | ||
| T1 (B220+AA4.1+ IgMhi CD23−) | 1.339 ± 0.377 | 1.546 ± 0.764 |
| T2 (B220+AA4.1+ IgMhi CD23+) | 0.504 ± 0.146 | 0.690 ± 0.305 |
| T3 (B220+AA4.1+ IgMlo CD23+) | 0.250 ± 0.098 | 0.314 ± 0.133 |
| Follicular (B220+ AA4.1− IgMloCD23+) | 26.02 ± 7.611 | 31.54 ± 7.607 |
| Marginal zone (B220+ AA4.1− IgMhi CD23−) | 7.960 ± 3.162 | 7.309 ± 2.278 |
a
Bone marrow cells were obtained from two femurs and tibias.
b
Cell number was calculated on the basis of total cell count and flow cytometric analysis. Data are shown as averages and standard deviations from six mice.