TABLE 2.
Invasive analysis of cardiac physiology in wild-type and 14-3-3τ+/− micea
| Genotype (nb) | HR (min−1) | LVPmax (mm Hg) | LVPed (mm Hg) | dP/dtmax (mm Hg/s) | dP/dtmin (mm Hg/s) | Tau (Weiss) (ms) |
|---|---|---|---|---|---|---|
| Wild type (5) | 534 ± 18 | 93 ± 12 | 5.0 ± 0.8 | 7,092 ± 2,529 | −7,644 ± 2,021 | 8.0 ± 0.8 |
| 14-3-3τ+/− (5) | 551 ± 37 | 94 ± 11 | 6.0 ± 2.0 | 6,209 ± 1,283 | −7,159 ± 1,606 | 9.0 ± 1.9 |
a
Twelve-week-old anesthetized mice underwent invasive cardiac catheterization. HR, heart rate; LVPmax, left ventricular peak systolic pressure; LVPed, left ventricular end-diastolic pressure; dP/dtmax, maximal change in pressure per unit of time; dP/dtmin, minimal change in pressure per unit of time; Tau, calculated index of diastolic function.
b
n, number of mice studied.